Article
A role for genetic susceptibility in sporadic focal segmental glomerulosclerosis.
The Journal of clinical investigation - 1 Mar 2016
Yu Haiyang, Artomov Mykyta, Brähler Sebastian, Stander M Christine, Shamsan Ghaidan, Sampson Matthew G, White J Michael, Kretzler Matthias, Miner Jeffrey H, Jain Sanjay, Winkler Cheryl A, Mitra Robi D, Kopp Jeffrey B, Daly Mark J, Shaw Andrey S
Abstract excerpt
Focal segmental glomerulosclerosis (FSGS) is a syndrome that involves kidney podocyte dysfunction and causes chronic kidney disease. Multiple factors including chemical toxicity, inflammation, and infection underlie FSGS; however, highly penetrant disease genes have been identified in a small fraction of patients with a family history of FSGS. Variants of apolipoprotein L1 (APOL1) have been linked to FSGS in...
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