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Orf Virus VIR Antagonizes p53-Mediated Antiviral Effects to Facilitate Viral Replication

21 Apr 2020

Abstract excerpt

As a zoonotic disease, ovine contagious pustular dermatitis (Orf) is a serious threat to sheep as well as humans. Orf virus (ORFV) interferon resistance protein (VIR) is the principal virulence protein that encodes a dsRNA-binding protein to inhibit host antiviral response. p53 is one of the key proteins of the host antiviral innate immunity. It not only enhances type I interferon secretion but also induces...

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PMID: 32315577
DOI: 10.1089/vim.2019.0189

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