Article
A parapoxviral virion protein targets the retinoblastoma protein to inhibit NF-κB signaling.
PLoS pathogens - 1 Dec 2017
Nagendraprabhu Ponnuraj, Khatiwada Sushil, Chaulagain Sabal, Delhon Gustavo, Rock Daniel L
Abstract excerpt
Poxviruses have evolved multiple strategies to subvert signaling by Nuclear Factor κB (NF-κB), a crucial regulator of host innate immune responses. Here, we describe an orf virus (ORFV) virion-associated protein, ORFV119, which inhibits NF-κB signaling very early in infection (≤ 30 min post infection). ORFV119 NF-κB inhibitory activity was found unimpaired upon translation inhibition, suggesting that virion...
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