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The whole genome analysis of the wild-type and attenuated orf virus reveals that ORF022 facilitates viral replication

15 May 2025

Abstract excerpt

BACKGROUND: Contagious ecthyma is an acute infectious zoonosis caused by orf virus (ORFV). Live-attenuated ORFV vaccines have played a crucial role in preventing contagious ecthyma for decades. However, these vaccines often fail to induce long-lasting immunity. In recent years, numerous ORFV genome sequences have been published, yet genomic data for attenuated strains remain limited. Furthermore, no comprehensive...

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PMID: 40375129
DOI: 10.1186/s12864-025-11663-1

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