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Orf virus ORFV112, ORFV117 and ORFV127 contribute to ORFV IA82 virulence in sheep.

Veterinary microbiology - 1 Jun 2021

Martins Mathias, Rodrigues Fernando S, Joshi Lok R, Jardim José C, Flores Mariana M, Weiblen Rudi, Flores Eduardo F, Diel Diego G

Abstract excerpt

The parapoxvirus orf virus (ORFV) encodes several immunomodulatory proteins (IMPs) that modulate host innate and pro-inflammatory responses to infection. Using the ORFV IA82 strain as the parental virus, recombinant viruses with individual deletions in the genes encoding the IMPs chemokine binding protein (CBP; ORFV112), inhibitor of granulocyte-monocyte colony-stimulating factor and IL-2 (GIF, ORFV117) and...

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Identifiers

PMID: 33866062
DOI: 10.1016/j.vetmic.2021.109066

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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