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Development and clinical evaluation of a CRISPR/Cas13a-based diagnostic test to detect Mycobacterium tuberculosis in clinical specimens

3 Feb 2023

Abstract excerpt

Objective Tuberculosis diagnosis requires rapid, simple and highly sensitive methods. Clustered regularly interspaced short palindromic repeats (CRISPRs) and associated protein (Cas) systems are increasingly being used for clinical diagnostic applications, due to their high flexibility, sensitivity and specificity. We developed a sensitive Mycobacterium tuberculosis (MTB) complex polymerase chain reaction...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 36819015
DOI: 10.3389/fmicb.2023.1117085

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