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Identification of Mycobacterium tuberculosis intracellular survival-related virulence factors via CRISPR-based eukaryotic-like secretory protein mutant library screen

12 Jun 2025

Abstract excerpt

ABSTRACT Tuberculosis (TB), caused by Mycobacterium tuberculosis ( M.tb ), remains a serious infectious disease posing significant global health challenges. A critical evolutionary feature of M.tb is its genome encoding a set of eukaryotic-like secretory proteins, which facilitate intracellular survival by manipulating host immune responses. However, the specific eukaryotic-like secretory proteins that facilitate...

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PMID: 40503836
DOI: 10.1128/spectrum.00767-25

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