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Article

Seriniquinones as Therapeutic Leads for Treatment of BRAF and NRAS Mutant Melanomas.

Molecules (Basel, Switzerland) - 4 Dec 2021

Hirata Amanda S, Rezende-Teixeira Paula, Machado-Neto João Agostinho, Jimenez Paula C, Clair James J La, Fenical William, Costa-Lotufo Leticia V

Abstract excerpt

Isolated from the marine bacteria Serinicoccus sp., seriniquinone (SQ1) has been characterized by its selective activity in melanoma cell lines marked by its modulation of human dermcidin and induction of autophagy and apoptosis. While an active lead, the lack of solubility of SQ1 in both organic and aqueous media has complicated its preclinical evaluation. In response, our team turned its effort to explore...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34885944
DOI: 10.3390/molecules26237362
PMCID: PMC8658889

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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