Article
In vivo antitumoral effect of 4-nerolidylcatechol (4-NC) in NRAS-mutant human melanoma.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association - 1 Jul 2020
Alves-Fernandes Débora Kristina, Oliveira Érica Aparecida de, Hastreiter Araceli Aparecida, Faião-Flores Fernanda, Felipe-Silva Aloisio Souza, Turato Walter, Fock Ricardo Ambrósio, Maria-Engler Silvya Stuchi, Barros Silvia Berlanga de Moraes
Abstract excerpt
NRAS-mutations arise in 15-20% of all melanomas and are associated with aggressive disease and poor prognosis. Besides, the treatment for NRAS-mutant melanoma are not very efficient and is currently limited to immune checkpoints inhibitors or aggressive chemotherapy. 4-nerolidylcathecol (4-NC), a natural product extracted from Pothomorphe umbellata, induces apoptosis in melanoma cells by ROS production, DNA...
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