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Article

β,β-Dimethylacrylshikonin Induces Apoptosis in Melanoma Cell Lines by NOXA Upregulation.

Journal of natural products - 28 Feb 2020

Stallinger Alexander, Kretschmer Nadine, Kleinegger Florian, Brvar Luka, Liegl-Atzwanger Bernadette, Prokesch Andreas, Durchschein Christin, Bauer Rudolf, Deutsch Alexander, Rinner Beate

Abstract excerpt

Melanoma is the most aggressive form of skin cancer, with high metastasis rates and poor prognosis. Survival rates and possible therapies depend on the state of the tumor and its mutational profile. BRAF and NRAS are the most frequent driver mutations. Currently, there is no efficient therapy for NRAS-mutated or late-stage melanoma. In this study, the therapeutic potential of β,β-dimethylacrylshikonin (DMAS) was...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 31961147
DOI: 10.1021/acs.jnatprod.9b00719

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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