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Article

α-Mangostin, a Natural Agent, Enhances the Response of NRAS Mutant Melanoma to Retinoic Acid.

Medical science monitor : international medical journal of experimental and clinical research - 22 Apr 2016

Xia Yun, Chen Jing, Gong Chongwen, Chen Hongxiang, Sun Jiaming

Abstract excerpt

BACKGROUND The identification and use of novel compounds alone or in combination hold promise for the fight against NRAS mutant melanoma. MATERIAL AND METHODS We screened a kinase-specific inhibitor library through combining it with α-Mangostin in NRAS mutant melanoma cell line, and verified the enhancing effect of α-Mangostin through inhibition of the tumorigenesis pathway. RESULTS Within the kinase inhibitors,...

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Identifiers

PMID: 27104669
DOI: 10.12659/msm.898204
PMCID: PMC4844330

Genes

NRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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