Article
Violacein induces death of RAS-mutated metastatic melanoma by impairing autophagy process.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine - 1 Oct 2016
Gonçalves Paola R, Rocha-Brito Karin J P, Fernandes Maruska R N, Abrantes Julia L, Durán Nelson, Ferreira-Halder Carmen V
Abstract excerpt
Treatment of metastatic melanoma still remains a challenge, since in advanced stage it is refractory to conventional treatments. Most patients with melanoma have either B-RAF or N-RAS mutations, and these oncogenes lead to activation of the RAS-RAF-MEK-ERK and AKT signal pathway, keeping active the proliferation and survival pathways in the cell. Therefore, the identification of small molecules that block...
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