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Article

Dityrosine Crosslinking of Collagen and Amyloid-β Peptides Is Formed by Vitamin B12 Deficiency-Generated Oxidative Stress in Caenorhabditis elegans.

International journal of molecular sciences - 30 Nov 2021

Koseki Kyohei, Yamamoto Aoi, Tanimoto Keisuke, Okamoto Naho, Teng Fei, Bito Tomohiro, Yabuta Yukinori, Kawano Tsuyoshi, Watanabe Fumio

Abstract excerpt

(1) Background: Vitamin B12 deficiency in Caenorhabditis elegans results in severe oxidative stress and induces morphological abnormality in mutants due to disordered cuticle collagen biosynthesis. We clarified the underlying mechanism leading to such mutant worms due to vitamin B12 deficiency. (2) Results: The deficient worms exhibited decreased collagen levels of up to approximately 59% compared with the...

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Identifiers

PMID: 34884761
DOI: 10.3390/ijms222312959
PMCID: PMC8657800

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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