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Expression profile of Caenorhabditis elegans mutant for the Werner syndrome gene ortholog reveals the impact of vitamin C on development to increase life span.

BMC genomics - 27 Oct 2014

Dallaire Alexandra, Proulx Sophie, Simard Martin J, Lebel Michel

Abstract excerpt

BACKGROUND: Werner Syndrome (WS) is a rare disorder characterized by the premature onset of a number of age-related diseases. The gene responsible for WS encodes a DNA helicase/exonuclease protein believed to affect different aspects of transcription, replication, and DNA repair. Caenorhabditis elegans (C. elegans) with a nonfunctional wrn-1 DNA helicase ortholog also exhibits a shorter life span, which can be...

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PMID: 25346348
DOI: 10.1186/1471-2164-15-940
PMCID: PMC4221712

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