Article
Functional role and ribosomal position of the unique N-terminal region of DHX29, a factor required for initiation on structured mammalian mRNAs.
Nucleic acids research - 16 Dec 2021
Sweeney Trevor R, Dhote Vidya, Guca Ewelina, Hellen Christopher U T, Hashem Yaser, Pestova Tatyana V
Abstract excerpt
Translation initiation on structured mammalian mRNAs requires DHX29, a DExH protein that comprises a unique 534-aa-long N-terminal region (NTR) and a common catalytic DExH core. DHX29 binds to 40S subunits and possesses 40S-stimulated NTPase activity essential for its function. In the cryo-EM structure of DHX29-bound 43S preinitiation complexes, the main DHX29 density resides around the tip of helix 16 of 18S...
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