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Article

RNA helicase DDX19 stabilizes ribosomal elongation and termination complexes.

Nucleic acids research - 17 Feb 2017

Mikhailova Tatiana, Shuvalova Ekaterina, Ivanov Alexander, Susorov Denis, Shuvalov Alexey, Kolosov Peter M, Alkalaeva Elena

Abstract excerpt

The human DEAD-box RNA-helicase DDX19 functions in mRNA export through the nuclear pore complex. The yeast homolog of this protein, Dbp5, has been reported to participate in translation termination. Using a reconstituted mammalian in vitro translation system, we show that the human protein DDX19 is also important for translation termination. It is associated with the fraction of translating ribosomes. We show...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Peptide Chain Elongation, Translational

Share to Peptide Chain Termination, Translational

Share to Peptide Elongation Factor 1

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Identifiers

PMID: 28180304
DOI: 10.1093/nar/gkw1239
PMCID: PMC5605241

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