Article
Endoplasmic Reticulum Stress and the Lysosomal Pathway Play Crucial Roles in the Progression of βB2-Crystallin Mutation-Induced Congenital Cataracts in Mice.
Investigative ophthalmology & visual science - 3 Apr 2023
Xiao Wei, Yang Weimin, Zhang Xinyu, Deng Xiaoqian, Chen Xiaoyun
Abstract excerpt
Purpose: Congenital cataract is a major cause of visual impairment and childhood blindness; however, its underlying mechanism remains unclear. Here, we aimed to identify the roles of endoplasmic reticulum stress (ERS), lysosomal pathway, and lens capsule fibrosis during the progression of βB2-crystallin mutation-induced congenital cataract in mice. Methods: BetaB2-W151C knock-in mice were generated using the...
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