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JAG1/Notch Pathway Inhibition Induces Ferroptosis and Promotes Cataractogenesis

1 Jan 2025

Abstract excerpt

Cataracts remain the leading cause of visual impairment worldwide, yet the underlying molecular mechanisms, particularly in age-related cataracts (ARCs), are not fully understood. The Notch signaling pathway, known for its critical role in various degenerative diseases, may also contribute to ARC pathogenesis, although its specific involvement is unclear. This study investigates the role of Notch signaling in...

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PMID: 39796164
DOI: 10.3390/ijms26010307

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