Article
Zippered G-quadruplex/hemin DNAzyme: exceptional catalyst for universal bioanalytical applications.
Nucleic acids research - 16 Dec 2021
Li Jia, Wu Haiping, Yan Yurong, Yuan Taixian, Shu Yue, Gao Xin, Zhang Lu, Li Siqiao, Ding Shijia, Cheng Wei
Abstract excerpt
G-quadruplex (G4)/hemin DNAzyme is promising horseradish peroxidase (HRP)-mimic candidate in the biological field. However, its relatively unsatisfactory catalytic capacity limits the potential applications. Inspired by nature protease, we conducted a proximity-enhanced cofactor assembly strategy (PECA) to form an exceptional HRP mimic, namely zippered G4/hemin DNAzyme (Z-G4/H). The hybridization of short...
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