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A Versatile DNAzyme‐Amplified Protease‐Sensing Platform for Accurate Diagnosis of SARS‐CoV‐2 and Reliable Classification of Colorectal Cancer

6 Sept 2025

Abstract excerpt

Peptide-based biosensors are widely used for in vitro detection of protease activity but often suffer from the limited sensitivity, poor accuracy, and incompatibility with point-of-care testing (POCT) devices. Herein, we developed a versatile deoxyribozyme (DNAzyme)-amplified protease-sensing (DP) platform that integrates the positively charged oligopeptides with a negatively charged DNAzyme biocatalyst for...

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Share to Advanced biosensing and bioanalysis techniques
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PMID: 40913455
DOI: 10.1002/anie.202507241

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