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Article

Turn-off colorimetric sensor for sequence-specific recognition of single-stranded DNA based upon Y-shaped DNA structure.

Scientific reports - 13 Aug 2018

Zhang Hong, Li Xintong, He Fan, Zhao Mingqin, Ling Liansheng

Abstract excerpt

A novel turn-off colorimetric sensor for sequence-specific recognition of single-stranded DNA (ssDNA) was established by combining Y-shaped DNA duplex and G-quadruplex-hemin DNAzyme. A G-rich single-stranded DNA (Oligo-1) displays peroxidase mimicking catalytic activity due to the specific binding with hemin in the presence of K+, which was able to catalyze the oxidation of colorless...

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PMID: 30104740
DOI: 10.1038/s41598-018-30529-z
PMCID: PMC6089895

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