The protective gene dose effect of the APOE ε2 allele on gray matter volume in cognitively unimpaired individuals.

doi:10.1002/alz.12487

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Article

The protective gene dose effect of the APOE ε2 allele on gray matter volume in cognitively unimpaired individuals.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Jul 2022

Salvadó Gemma, Ferreira Daniel, Operto Grégory, Cumplido-Mayoral Irene, Arenaza-Urquijo Eider M, Cacciaglia Raffaele, Falcon Carles, Vilor-Tejedor Natàlia, Minguillon Carolina, Groot Colin, van der Flier Wiesje M, Barkhof Frederik, Scheltens Philip, Ossenkoppele Rik, Kern Silke, Zettergren Anna, Skoog Ingmar, Hort Jakub, Stomrud Erik, van Westen Danielle, Hansson Oskar, Molinuevo José Luis, Wahlund Lars-Olof, Westman Eric, Gispert Juan Domingo

Abstract excerpt

INTRODUCTION: Harboring two copies of the apolipoprotein E (APOE) ε2 allele strongly protects against Alzheimer's disease (AD). However, the effect of this genotype on gray matter (GM) volume in cognitively unimpaired individuals has not yet been described. METHODS: Multicenter brain magnetic resonance images (MRIs) from cognitively unimpaired ε2 homozygotes were matched (1:1) against all other APOE genotypes for...

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PMID: 34877786
DOI: 10.1002/alz.12487
PMCID: PMC9542211

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