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Article

Improving biophysical properties of a bispecific antibody scaffold to aid developability: quality by molecular design.

mAbs - 1 Jan 2000

Von Kreudenstein Thomas Spreter, Escobar-Carbrera Eric, Lario Paula I, D'Angelo Igor, Brault Karine, Kelly John, Durocher Yves, Baardsnes Jason, Woods R Jeremy, Xie Michael Hongwei, Girod Pierre-Alain, Suits Michael D L, Boulanger Martin J, Poon David K Y, Ng Gordon Y K, Dixit Surjit B

Abstract excerpt

While the concept of Quality-by-Design is addressed at the upstream and downstream process development stages, we questioned whether there are advantages to addressing the issues of biologics quality early in the design of the molecule based on fundamental biophysical characterization, and thereby reduce complexities in the product development stages. Although limited number of bispecific therapeutics are in...

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Identifiers

PMID: 23924797
DOI: 10.4161/mabs.25632
PMCID: PMC3851217

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