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Article

Restoring Retinoic Acid Attenuates Intestinal Inflammation and Tumorigenesis in APCMin/+ Mice.

Cancer immunology research - 1 Nov 2016

Penny Hweixian Leong, Prestwood Tyler R, Bhattacharya Nupur, Sun Fionna, Kenkel Justin A, Davidson Matthew G, Shen Lei, Zuniga Luis A, Seeley E Scott, Pai Reetesh, Choi Okmi, Tolentino Lorna, Wang Jinshan, Napoli Joseph L, Engleman Edgar G

Abstract excerpt

Chronic intestinal inflammation accompanies familial adenomatous polyposis (FAP) and is a major risk factor for colorectal cancer in patients with this disease, but the cause of such inflammation is unknown. Because retinoic acid (RA) plays a critical role in maintaining immune homeostasis in the intestine, we hypothesized that altered RA metabolism contributes to inflammation and tumorigenesis in FAP. To assess...

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Identifiers

PMID: 27638841
DOI: 10.1158/2326-6066.CIR-15-0038
PMCID: PMC5378314

Genes

FAP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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