Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

WDR26 and MTF2 are therapeutic targets in multiple myeloma

1 Dec 2021

Abstract excerpt

Unbiased genetic forward screening using retroviral insertional mutagenesis in a genetically engineered mouse model of human multiple myeloma may further our understanding of the genetic pathways that govern neoplastic plasma cell development. To evaluate this hypothesis, we performed a tumor induction study in MYC-transgenic mice infected as neonates with the Moloney-derived murine leukemia virus, MOL4070LTR....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Multiple Myeloma Research and Treatments
Share to Protein Degradation and Inhibitors
Share to Ubiquitin and proteasome pathways

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 34876184
DOI: 10.1186/s13045-021-01217-9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

WDR26 and MTF2 are therapeutic targets in multiple myelomaPMID 34876184Read ↗

Genome-wide association study identifies multiple susceptibility loci for multiple myeloma.Semantic proximity Read ↗

Germline Lysine-Specific Demethylase 1 (LSD1/KDM1A) Mutations Confer Susceptibility to Multiple Myeloma.Semantic proximity Read ↗

The genomic landscape of Vk*MYC myeloma highlights shared pathways of transformation between mice and humans.Semantic proximity Read ↗

A Transgenic Mouse Model of Plasma Cell Malignancy Shows Phenotypic, Cytogenetic, and Gene Expression Heterogeneity Similar to Human Multiple MyelomaSemantic proximity Read ↗

Generation of a novel, multi-stage, progressive, and transplantable model of plasma cell neoplasms.Semantic proximity Read ↗

Integrative analysis of WDR12 as a potential prognostic and immunological biomarker in multiple human tumorsSemantic proximity Read ↗

Whole Genome Sequence of Multiple Myeloma-Prone C57BL/KaLwRij Mouse Strain Suggests the Origin of Disease Involves Multiple Cell Types.Semantic proximity Read ↗

Identification of WNK1 as a therapeutic target to suppress IgH/MYC expression in multiple myelomaSemantic proximity Read ↗

Identification of molecular vulnerabilities in human multiple myeloma cells by RNA interference lethality screening of the druggable genome.Semantic proximity Read ↗

The epigenetic modifier JMJD6 is amplified in mammary tumors and cooperates with c-Myc to enhance cellular transformation, tumor progression, and metastasisSemantic proximity Read ↗

The Vk*MYC Mouse Model recapitulates human multiple myeloma evolution and genomic diversitySemantic proximity Read ↗

UTX/KDM6A Loss Enhances the Malignant Phenotype of Multiple Myeloma and Sensitizes Cells to EZH2 inhibition.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.