Article
Germline Lysine-Specific Demethylase 1 (LSD1/KDM1A) Mutations Confer Susceptibility to Multiple Myeloma.
Cancer research - 15 May 2018
Wei Xiaomu, Calvo-Vidal M Nieves, Chen Siwei, Wu Gang, Revuelta Maria V, Sun Jian, Zhang Jinghui, Walsh Michael F, Nichols Kim E, Joseph Vijai, Snyder Carrie, Vachon Celine M, McKay James D, Wang Shu-Ping, Jayabalan David S, Jacobs Lauren M, Becirovic Dina, Waller Rosalie G, Artomov Mykyta, Viale Agnes, Patel Jayeshkumar, Phillip Jude, Chen-Kiang Selina, Curtin Karen, Salama Mohamed, Atanackovic Djordje, Niesvizky Ruben, Landgren Ola, Slager Susan L, Godley Lucy A, Churpek Jane, Garber Judy E, Anderson Kenneth C, Daly Mark J, Roeder Robert G, Dumontet Charles, Lynch Henry T, Mullighan Charles G, Camp Nicola J, Offit Kenneth, Klein Robert J, Yu Haiyuan, Cerchietti Leandro, Lipkin Steven M
Abstract excerpt
Given the frequent and largely incurable occurrence of multiple myeloma, identification of germline genetic mutations that predispose cells to multiple myeloma may provide insight into disease etiology and the developmental mechanisms of its cell of origin, the plasma cell (PC). Here, we identified familial and early-onset multiple myeloma kindreds with truncating mutations in lysine-specific demethylase 1...
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