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Article

Effects of Increasing Concentrations of Rifampicin on Different Mycobacterium tuberculosis Lineages in a Whole-Blood Bactericidal Activity Assay.

Antimicrobial agents and chemotherapy - 15 Feb 2022

Verma Rupangi, Gurumurthy Meera, Yeo Benjamin Chaik Meng, Lu Qingshu, Naftalin Claire M, Paton Nicholas I

Abstract excerpt

High-dose rifampicin improved bactericidal activity and culture conversion in early-phase tuberculosis (TB) trials, done mainly in Africa. We performed a whole-blood bactericidal activity (WBA) study to determine whether the effects of high-dose rifampicin differ across globally relevant TB strains and whether effects are similar in dormant bacilli that will be required for enhancing cure. Whole blood from...

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Identifiers

PMID: 34871090
DOI: 10.1128/AAC.01699-21
PMCID: PMC8846316

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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