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O-GlcNAcylation in Chronic Lymphocytic Leukemia and Other Blood Cancers

18 Nov 2021

Abstract excerpt

In the past decade, aberrant O-GlcNAcylation has emerged as a new hallmark of cancer. O-GlcNAcylation is a post-translational modification that results when the amino-sugar β-D-N-acetylglucosamine (GlcNAc) is made in the hexosamine biosynthesis pathway (HBP) and covalently attached to serine and threonine residues in intracellular proteins by the glycosyltransferase O-GlcNAc transferase (OGT). O-GlcNAc moieties...

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PMID: 34868034
DOI: 10.3389/fimmu.2021.772304

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