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Post-translational modifications of cancer immune checkpoints: mechanisms and therapeutic strategies

8 Jul 2025

Abstract excerpt

Immunotherapies, particularly immune checkpoint inhibitors (ICIs), have revolutionized cancer clinical management, but low response rates and treatment resistance remain challenging. Protein post-translational modifications (PTMs) are critical for governing protein expression, localization, functions, and interactions with other cellular molecules, which notably build up the diversity and complexity of the...

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PMID: 40629335
DOI: 10.1186/s12943-025-02397-5

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