Article

Broadly-recognized, cross-reactive SARS-CoV-2 CD4 T cell epitopes are highly conserved across human coronaviruses and presented by common HLA alleles

2022-01-22

Abstract excerpt

<h4>Summary</h4> Sequence homology between SARS-CoV-2 and common-cold human coronaviruses (HCoVs) raises the possibility that memory responses to prior HCoV infection can impact the T cell response in COVID-19. We studied T cells recognizing SARS-CoV-2 and HCoVs in convalescent COVID-19 donors, and identified a highly conserved SARS-CoV-2 sequence S 811-831 , with two overlapping epitopes presented by common MHC...

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Literature Corpus work: ded900ac-4cee-5b60-b4cc-7239d092ddc9
DOI: 10.1101/2022.01.20.477107

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