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Article

SARS-CoV-2-specific CD4+ and CD8+ T cell responses can originate from cross-reactive CMV-specific T cells

21 Nov 2022

Abstract excerpt

Detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) specific CD4 + and CD8 + T cells in SARS-CoV-2-unexposed donors has been explained by the presence of T cells primed by other coronaviruses. However, based on the relatively high frequency and prevalence of cross-reactive T cells, we hypothesized cytomegalovirus (CMV) may induce these cross-reactive T cells. Stimulation of pre-pandemic...

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PMID: 36408799
DOI: 10.7554/elife.82050

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