Article
An adaptive method of defining negative mutation status for multi-sample comparison using next-generation sequencing.
BMC medical genomics - 2 Dec 2021
Hutson Nicholas, Zhan Fenglin, Graham James, Murakami Mitsuko, Zhang Han, Ganaparti Sujana, Hu Qiang, Yan Li, Ma Changxing, Liu Song, Xie Jun, Wei Lei
Abstract excerpt
BACKGROUND: Multi-sample comparison is commonly used in cancer genomics studies. By using next-generation sequencing (NGS), a mutation's status in a specific sample can be measured by the number of reads supporting mutant or wildtype alleles. When no mutant reads are detected, it could represent either a true negative mutation status or a false negative due to an insufficient number of reads, so-called...
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