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A novel antibody against the furin cleavage site of SARS-CoV-2 spike protein: Effects on proteolytic cleavage and ACE2 binding.

Immunology letters - 1 Feb 2022

Spelios Michael G, Capanelli Jeanne M, Li Adam W

Abstract excerpt

SARS-CoV-2 harbors a unique S1/S2 furin cleavage site within its spike protein, which can be cleaved by furin and other proprotein convertases. Proteolytic activation of SARS-CoV-2 spike protein at the S1/S2 boundary facilitates interaction with host ACE2 receptor for cell entry. To address this, high titer antibody was generated against the SARS-CoV-2-specific furin motif. Using a series of innovative...

Topics

Amino Acid Motifs
Angiotensin-Converting Enzyme 2
Antibodies, Viral
Furin
Humans
Mutation
Nose
Proprotein Convertases
Protein Binding
Proteolysis
SARS-CoV-2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Spike Glycoprotein, Coronavirus

Source

Open in PubMed Open full text

Identifiers

PMID: 35007661
DOI: 10.1016/j.imlet.2022.01.002
PMCID: PMC8739817

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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