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Article

Controlled RISC loading efficiency of miR168 defined by miRNA duplex structure adjusts ARGONAUTE1 homeostasis.

Nucleic acids research - 16 Dec 2021

Dalmadi Ágnes, Miloro Fabio, Bálint Jeannette, Várallyay Éva, Havelda Zoltán

Abstract excerpt

Micro RNAs (miRNAs) are processed from precursor RNA molecules with precisely defined secondary stem-loop structures. ARGONAUTE1 (AGO1) is the main executor component of miRNA pathway and its expression is controlled via the auto-regulatory feedback loop activity of miR168 in plants. Previously we have shown that AGO1 loading of miR168 is strongly restricted leading to abundant cytoplasmic accumulation of...

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Identifiers

PMID: 34850097
DOI: 10.1093/nar/gkab1138
PMCID: PMC8682782

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