Article
Argonaute quenching and global changes in Dicer homeostasis caused by a pathogen-encoded GW repeat protein.
Genes & development - 1 May 2010
Azevedo Jacinthe, Garcia Damien, Pontier Dominique, Ohnesorge Stephanie, Yu Agnes, Garcia Shahinez, Braun Laurence, Bergdoll Marc, Hakimi Mohamed Ali, Lagrange Thierry, Voinnet Olivier
Abstract excerpt
In plants and invertebrates, viral-derived siRNAs processed by the RNaseIII Dicer guide Argonaute (AGO) proteins as part of antiviral RNA-induced silencing complexes (RISC). As a counterdefense, viruses produce suppressor proteins (VSRs) that inhibit the host silencing machinery, but their mechanisms of action and cellular targets remain largely unknown. Here, we show that the Turnip crinckle virus (TCV) capsid,...
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