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Article

AGO1 homeostasis involves differential production of 21-nt and 22-nt miR168 species by MIR168a and MIR168b.

PloS one - 30 Jul 2009

Vaucheret Hervé

Abstract excerpt

BACKGROUND: AGO1 associates with microRNAs (miRNAs) and regulates mRNAs through cleavage and translational repression. AGO1 homeostasis entails DCL1-dependent production of miR168 from MIR168a and MIR168b transcripts, post-transcriptional stabilization of miR168 by AGO1, and AGO1-catalyzed miR168-guided cleavage of AGO1 mRNA. PRINCIPAL FINDINGS: This study reveals that MIR168a is highly expressed and...

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Identifiers

PMID: 19649244
DOI: 10.1371/journal.pone.0006442
PMCID: PMC2714465

Genes

AGO1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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