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Article

Pleiotropy or linkage? Their relative contributions to the genetic correlation of quantitative traits and detection by multitrait GWA studies.

Genetics - 10 Dec 2021

Chebib Jobran, Guillaume Frédéric

Abstract excerpt

Genetic correlations between traits may cause correlated responses to selection. Previous models described the conditions under which genetic correlations are expected to be maintained. Selection, mutation, and migration are all proposed to affect genetic correlations, regardless of whether the underlying genetic architecture consists of pleiotropic or tightly linked loci affecting the traits. Here, we...

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PMID: 34849850
DOI: 10.1093/genetics/iyab159
PMCID: PMC8664587

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