Article
Focused goodness of fit tests for gene set analyses.
Briefings in bioinformatics - 17 Jan 2022
Zhang Mengqi, Gelfman Sahar, Martins Moreno Cristiane Araujo, McCarthy Janice M, Harms Matthew B, Goldstein David B, Allen Andrew S
Abstract excerpt
Gene set-based signal detection analyses are used to detect an association between a trait and a set of genes by accumulating signals across the genes in the gene set. Since signal detection is concerned with identifying whether any of the genes in the gene set are non-null, a goodness-of-fit (GOF) test can be used to compare whether the observed distribution of gene-level tests within the gene set agrees with...
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