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Article

An approach to gene-based testing accounting for dependence of tests among nearby genes.

Briefings in bioinformatics - 5 Nov 2021

Yurko Ronald, Roeder Kathryn, Devlin Bernie, G'Sell Max

Abstract excerpt

In genome-wide association studies (GWAS), it has become commonplace to test millions of single-nucleotide polymorphisms (SNPs) for phenotypic association. Gene-based testing can improve power to detect weak signal by reducing multiple testing and pooling signal strength. While such tests account for linkage disequilibrium (LD) structure of SNP alleles within each gene, current approaches do not capture LD of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34459489
DOI: 10.1093/bib/bbab329
PMCID: PMC8575037

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