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Article

Discrepancy between recipient and donor rs4364254 heparanase single nucleotide polymorphism impacts graft-versus-host disease after allogeneic stem cell transplant.

International journal of laboratory hematology - 1 Dec 2023

Metafuni Elisabetta, Giammarco Sabrina, Bellesi Silvia, Rossi Monica, Minnella Gessica, Limongiello Maria Assunta, Valentini Caterina Giovanna, Teofili Luciana, Sica Simona, Chiusolo Patrizia

Abstract excerpt

INTRODUCTION: The heparanase (HPSE) gene is highly polymorphic, but only a minority of its single nucleotide polymorphisms (SNPs) have been studied. Among these, rs4693608 and rs4364254 SNPs are closely associated with mRNA expression and HPSE protein levels in healthy subjects. Given the association between HPSE and inflammatory response, we aimed to evaluate whether HPSE rs4693608 and rs4364254 SNPs could have...

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PMID: 37646104
DOI: 10.1111/ijlh.14159

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