The HPSE Gene Insulator-A Novel Regulatory Element That Affects Heparanase Expression, Stem Cell Mobilization, and the Risk of Acute Graft versus Host Disease.

doi:10.3390/cells10102523

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The HPSE Gene Insulator-A Novel Regulatory Element That Affects Heparanase Expression, Stem Cell Mobilization, and the Risk of Acute Graft versus Host Disease.

Cells - 23 Sept 2021

Ostrovsky Olga, Baryakh Polina, Morgulis Yan, Mayorov Margarita, Bloom Nira, Beider Katia, Shimoni Avichai, Vlodavsky Israel, Nagler Arnon

Abstract excerpt

The HPSE gene encodes heparanase (HPSE), a key player in cancer, inflammation, and autoimmunity. We have previously identified a strong HPSE gene enhancer involved in self-regulation of heparanase by negative feedback exerted in a functional rs4693608 single-nucleotide polymorphism (SNP) dependent manner. In the present study, we analyzed the HPSE gene insulator region, located in intron 9 and containing...

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PMID: 34685503
DOI: 10.3390/cells10102523
PMCID: PMC8534152

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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