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Article

Distinct Morphological and Behavioural Alterations in ENU-Induced Heterozygous Trpc7K810Stop Mutant Mice.

Genes - 29 Oct 2021

Rathkolb Birgit, Howaldt Maike, Krebs Stefan, Prückl Petra, Sauer Susanne, Hrabě de Angelis Martin, Aigner Bernhard

Abstract excerpt

Trpc7 (transient receptor potential cation channel, subfamily C, member 7; 862 amino acids) knockout mice are described showing no clear phenotypic alterations, therefore, the functional relevance of the gene remains unclear. A complementary approach for the functional analysis of a given gene is the examination of individuals harbouring a mutant allele of the gene. In the phenotype-driven Munich ENU mouse...

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Identifiers

PMID: 34828338
DOI: 10.3390/genes12111732
PMCID: PMC8617871

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