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Article

The Moonwalker mouse: new insights into TRPC3 function, cerebellar development, and ataxia.

Cerebellum (London, England) - 1 Oct 2014

Becker Esther B E

Abstract excerpt

The Moonwalker (Mwk) mouse is a recent model of dominantly inherited cerebellar ataxia. The motor phenotype of the Mwk mouse is due to a gain-of-function mutation in the gene encoding the cation-permeable transient receptor potential channel (TRPC3). This mutation converts a threonine into an alanine in the highly conserved cytoplasmic S4-S5 linker of the channel, affecting channel gating. TRPC3 is highly...

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Identifiers

PMID: 24797279
DOI: 10.1007/s12311-014-0564-5
PMCID: PMC4155175

Genes

TRPC3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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