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Article

Cutting edge: a natural P451L mutation in the cytoplasmic domain impairs the function of the mouse P2X7 receptor.

Journal of immunology (Baltimore, Md. : 1950) - 15 Oct 2002

Adriouch Sahil, Dox Claudia, Welge Vivienne, Seman Michel, Koch-Nolte Friedrich, Haag Friedrich

Abstract excerpt

The P2X7 receptor (P2X(7)R) is an ATP-gated channel that mediates apoptosis of cells of the immune system. The capacity of P2X(7)R to form large pores depends on its large cytoplasmic tail, which harbors a putative TNFR-related death domain. Previous transfection studies indicated that mouse P2X(7)R forms pores much less efficiently than its counterparts from humans and rats. In this study, we demonstrate that an...

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PMID: 12370338
DOI: 10.4049/jimmunol.169.8.4108

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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