Article
Interrogation of the microenvironmental landscape in spinal ependymomas reveals dual functions of tumor-associated macrophages.
Nature communications - 25 Nov 2021
Zhang Qianqian, Cheng Sijin, Wang Yongzhi, Wang Mengdi, Lu Yufeng, Wen Zengqi, Ge Yuxin, Ma Qiang, Chen Youqiao, Zhang Yaowu, Cao Ren, Li Min, Liu Weihao, Wang Bo, Wu Qian, Jia Wenqing, Wang Xiaoqun
Abstract excerpt
Spinal ependymomas are the most common spinal cord tumors in adults, but their intratumoral cellular heterogeneity has been less studied, and how spinal microglia are involved in tumor progression is still unknown. Here, our single-cell RNA-sequencing analyses of three spinal ependymoma subtypes dissect the microenvironmental landscape of spinal ependymomas and reveal tumor-associated macrophage (TAM) subsets...
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