Article

Yeast and Mammalian Epsins Use Different Determinants for Localization and Function: Role of Clathrin/AP2/Ubiquitin Binding Motifs and Poly-Glutamine Stretches

2022-08-05

Abstract excerpt

<h4>ABSTRACT</h4> Epsins are endocytic adaptor proteins involved in the internalization of important membrane proteins such as EGFR and Notch ligands. Therefore, this protein family impacts critical signaling pathways and processes such as cell migration and cytokinesis and is ultimately required for embryo development in mammals and cell viability in yeast. Intriguingly, although Epsins are conserved and display...

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Literature Corpus work: 24c1b757-1247-5b13-9c0a-fac109bb4245
DOI: 10.1101/2022.08.04.502746

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