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An evolutionary switch in the specificity of an endosomal CORVET tether underlies formation of regulated secretory vesicles in the ciliate <i>Tetrahymena thermophila</i>

2017-10-27

Abstract excerpt

<h4>Summary</h4> In the endocytic pathway of animals, two related complexes, called CORVET (Class C Core Vacuole/Endosome Transport) and HOPS (Homotypic fusion and protein sorting), act as both tethers and fusion factors for early and late endosomes, respectively. Mutations in CORVET or HOPS lead to trafficking defects and contribute to human disease including immune dysfunction. HOPS and CORVET are conserved thr...

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Literature Corpus work
0365d680-5759-575b-9003-58180955c16f
DOI
10.1101/210328
Open publication

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