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Article

Molecular basis for coupling the plasma membrane to the actin cytoskeleton during clathrin-mediated endocytosis.

Proceedings of the National Academy of Sciences of the United States of America - 18 Sept 2012

Skruzny Michal, Brach Thorsten, Ciuffa Rodolfo, Rybina Sofia, Wachsmuth Malte, Kaksonen Marko

Abstract excerpt

Dynamic actin filaments are a crucial component of clathrin-mediated endocytosis when endocytic proteins cannot supply enough energy for vesicle budding. Actin cytoskeleton is thought to provide force for membrane invagination or vesicle scission, but how this force is transmitted to the plasma membrane is not understood. Here we describe the molecular mechanism of plasma membrane-actin cytoskeleton coupling...

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Identifiers

PMID: 22927393
DOI: 10.1073/pnas.1207011109
PMCID: PMC3458359

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