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Article

LSD1 inhibition sustains T cell invigoration with a durable response to PD-1 blockade

24 Nov 2021

Abstract excerpt

Abstract Exhausted CD8+ T cells are key targets of immune checkpoint blockade therapy and their ineffective reinvigoration limits the durable benefit in some cancer patients. Here, we demonstrate that histone demethylase LSD1 acts to enforce an epigenetic program in progenitor exhausted CD8+ T cells to antagonize the TCF1-mediated progenitor maintenance and to promote terminal differentiation. Consequently,...

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PMID: 34819502
DOI: 10.1038/s41467-021-27179-7

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