Article
Bap31 is an itinerant protein that moves between the peripheral endoplasmic reticulum (ER) and a juxtanuclear compartment related to ER-associated Degradation.
Molecular biology of the cell - 1 May 2008
Wakana Yuichi, Takai Sawako, Nakajima Ken-Ichi, Tani Katsuko, Yamamoto Akitsugu, Watson Peter, Stephens David J, Hauri Hans-Peter, Tagaya Mitsuo
Abstract excerpt
Certain endoplasmic reticulum (ER)-associated degradation (ERAD) substrates with transmembrane domains are segregated from other ER proteins and sorted into a juxtanuclear subcompartment, known as the ER quality control compartment. Bap31 is an ER protein with three transmembrane domains, and it is assumed to be a cargo receptor for ER export of some transmembrane proteins, especially those prone to ERAD. Here,...
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